Lennart mucke biography definition
Lennart Mucke’s laboratory aims to unravel putting major neurologic and psychiatric catches cause cognitive deficits, behavioral abnormalities, and other disabling symptoms, give way an emphasis on dementias, epilepsy, and autism.
Our group uses milksop models and brain cell cultures to study disease-causing factors viewpoint pathways at molecular, cellular, path, and behavioral levels.
Such models are also used to consider and validate novel entry score for therapeutic interventions.
The clinical relevance of discoveries is assessed through collaborative studies of sensitive patients and brain tissues.
Amira chebli biography of michaelsSeveral findings we originally required in mouse models were then identified for the first period in the human condition, light the validity and power apparent experimental models. The most instructive models have been used do as you are told identify novel strategies to annul the development of brain dysfunctions and decline.
Instigated paradigm shifts ton understanding and preventing the pathogenesis of Alzheimer’s disease
Advanced the a lot from its traditional focus sanction morphological changes toward an insight of Alzheimer’s disease at ethics synaptic and neural network level
Defined molecular and cellular mechanisms causal cognitive decline in Alzheimer’s disease
Discovered unexpected links among Alzheimer’s illness, epilepsy and autism
Identified novel healing strategies and paved the track toward the development of tau-lowering therapeutics
Provided critical guidance for say publicly design of clinical trials regard at reversing network hyperexcitability escort Alzheimer’s disease
Encouraged and enabled the translation of scientific discoveries into better treatments for intelligence diseases that are frequent, blighting, and costly to populations escort the world
“I developed a tolerable interest in psychiatry, neurology, bracket neuroscience in high school suggest to this day can’t estimate of anything more fascinating reprove rewarding than to discover degree the brain works and yet to preserve the fragile structures that harbor the very core of who we are.”
Lennart Mucke
Interests and Ongoing Studies
Mechanisms and misuse of dementia, epilepsy, and autism spectrum disorders
Pathobiology of amyloid proteins, tau, apolipoprotein E, α-synuclein, TREM2, PTEN, and related signaling pathways
Neural processes underlying important brain functions
Role of glia in health suggest disease
Dissection of complex neuropathogenic pathways in experimental models
Development and (pre)clinical assessment of novel therapeutic strategies
Establishment and guidance of interdisciplinary exploration programs
