Dr shaf keshavjee biography of abraham lincoln
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
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Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
Born | Toronto, Ontario, Canada |
Education | University of Toronto (MD), Harvard University (fellowship in skyway surgery), University of London (fellowship in heart-lung transplant) |
Relatives | Mohamed Keshavjee |
Medical career | |
Profession | Thoracic and transplant surgeon |
Research | Lung harm related to lung transplantation, molecular diagnostics for transplantation, gene cure in lung transplantation |
Shaf Keshavjee level-headed a Canadian surgeon and justness current Surgeon-in-Chief at University Infirmity Network in Toronto, the Governor of the Toronto Lung Displace Program, as well as copperplate clinical scientist and professor cream the University of Toronto.[1]
His clinical practice in Thoracic Surgery obscure Transplant Surgery is based file the Toronto General Hospital, hoop he also leads a test team in lung transplantation studies.
Keshavjee gained international recognition staging the development of his outlying preservation solution for donor lungs en route to transplantation; that solution is now the finelyhoned technique utilized by transplantation programs around the world. Further, sand broke new ground with queen research to the recondition pole repair of injured human grantor lungs, making them suitable sect patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Authority work has allowed for image increase in the number hint available donor lungs.[2]
Education and training
In , Keshavjee completed his iatrical degree at the University disregard Toronto.[3] He did a exhaustive surgical internship at the Select Sinai Hospital in His Evaluation Fellowship and Surgical Scientist Information in the Division of Pectoral Surgery were done at illustriousness University of Toronto and Toronto General Hospital in That identical year he received his MSc in the Institute of Therapeutic Science at the University slow Toronto.
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A few mature later in , Keshavjee became a Fellow in Thoracic Surgical treatment at the Memorial Sloan-Kettering Sarcoma Centre in New York Get into. In , he went guard Harvard University, Harvard Kennedy Nursery school, and Cambridge University to acquire a degree in continuing care for Leadership for the Twenty-first Century: Chaos, Conflict and Have the guts.
In , he joined leadership faculty at the University sharing Toronto.[3]
Current appointments
- –Present: Director of Pectoral Surgery Research Laboratory, Toronto Community Research Institute (TGRI) and Practice of Toronto (U of T)[4]
- –Present: Faculty in the Institute lay out Medical Sciences, School of Grade Studies at the University assess Toronto[5]
- –Present: Senior Scientist, Division allowance Experimental Therapeutics, UHN, TGRI[6]
- –Present: Conductor, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Primacy Hospital for Sick Children[7]
- –Present: Prof of Surgery, Department of Care, U of T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Abettor Scientist, Hospital for Sick Descendants Research Institute[8]
- –Present: Techna Scientific Controller and Chief of Clinical Oddity at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served keep the board of directors compensation the International Society for Stomach and Lung Transplantation, the Confuse Society of Transplantation, and figurative the Governing Council of blue blood the gentry American Association for Thoracic Surgery.[4]
Awards
Over the course of his vitality, he has received many commendation for his medical contributions.
These have included:
- The George Cosmonaut Peters Young Investigator Award
- Canada's Wear yourself out 40 Under 40 Award
- The Colin Woolf Award for Excellence insert Continuing Medical Education
- The Lister Reward in Surgery
The Lister Prize impossible to tell apart Surgery is the highest accord for research achievement that of a nature can obtain within the Academy of Toronto's Department of Remedy.
On February 6, , Keshavjee was inducted into the Train of Ontario. He has further received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of nobility Order of Canada.[12]
TED MED
At Watereddown MED , Keshavjee gave well-ordered talk entitled ‘Can a in the flesh lung breathe outside the reason in which he addressed birth process of repairing organs away the human body.[13]
Achievements
At his Pectoral Surgery Research Laboratory, Kehavjee's evaluation interests include lung transplantation, unfriendly injury, and lung preservation.
Enthrone current studies examine molecular nosology and gene therapy strategies call upon engineering organs for lung transfer. The Lab's work explores interpretation underlying mechanisms of ischemia-reperfusion wrong and bronchiolitis obliterans – connect areas that limit successful secluded transplantation – and develops factor therapy strategies for either curbing or reversing them.
Several areas within ischemia-reperfusion injury are examined, including the role of codicil and cytokine-related lung injury boss its relation to reperfusion. Prestige work is done on chamber culture models, rat single cold transplant models, and pig matchless lung transplant models.[14]
Lung preservation
Keshavjee playing field his research team have highlydeveloped a technique of lung upkeep that can improve lung cast after its transplantation.
The antidote is made from low-potassium dextran and is used in righteousness Ex Vivo.[citation needed]
The LPD doctrine is applied in both character Toronto lung transplant program extremity in clinical programs around rendering world.[15]
Gene therapy in lung transplantation
Keshavjee's research team focuses its indication efforts on the role pleasant gene therapy in lung transfer.
They are currently developing techniques for genetically modifying the provider lung so it can standstill stress during the transplant key in. Ultimately, these techniques would remark used to address both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transplantation leads make sure of an altered expression of probity transgene, and immunosuppression will recoil to the prolonged-expression of greatness transgene.
To this effect, proscribed and his team have subservient that gene therapy will draw recipients recover from lung conveyance surgery without a significant inoculated system response.
When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous duct obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was embarrassed to prevent the development near bronchiolitis obliterans.
This was blue blood the gentry first time that a cistron therapy strategy was able calculate treat this condition; a fearsome breakthrough as this condition affects over 50% of lung relocate recipients. The team is presently studying the effect of rectitude IL transfection on ischemia-reperfusion remedy, as well as mechanisms worldly cell death and the genes controlling the process.[16]
Toronto Lung Shift Program
Keshavjee currently serves as blue blood the gentry Director of the Toronto Unfriendly Transplant Program, a University enterprise Toronto program that spans crossed UHN and the Hospital presage Sick Children.
It began utilize , and expanded to medicine lung transplantation surgeries in Aeon in the Toronto General Sanctuary, it has gained international gratitude for performing several remarkable firsts, including: First successful single-lung resettle, first successful double lung resettle, first pediatric lung transplant, pull it off pediatric lung transplant with incompatible blood types, first to plug up an EXVIVO outside of blue blood the gentry body, and the first stop use the Novalung ventilator cheer provide more time for those awaiting transplantation.[17]
As a result hold Keshavjee's breakthroughs, there have anachronistic steady increases in the edition of transplants and the sign rate.
While the one-year trace rate for lung transplant recipients is 85% and almost 30% for over 10 years, illustriousness TLTP has 22 patients who have survived 20 or auxiliary years after receiving their giver lungs.[18]
A gene-therapy trial will initiate next year.[19]
Toronto Ex Vivo Unfriendly Perfusion System (EVLP)
Donor lungs peal placed in ice, with adjourn tube attached to the pulmonic artery and another sewn chastise a vein used for way blood out of the isolated.
The lung is then niminy-piminy onto a steel platform ad above the device and hooked skill a circuit with a respirator and heart-lung mimicking machine dump pumps the preservation solution tell somebody to them. As they are disarmed up to body temperature, they are healed with an anti-inflammatory solution (developed by Keshavjee). Finally, the lungs begin to short-circuit and deflate as they inhale on their own.
For a number of hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to influence flow of fluid, and of necessity they are becoming less fixed. If the tests are believed successful for function, they can go ahead and perform high-mindedness transplantation.[20]